锯齿状息肉综合征患者发生的三例结肠腺癌：病例报告及文献复习
Three Colon Adenocarcinomas Arising in a Patient with Serrated Polyposis Syndrome: Case Report and Review of the Literature.
作者信息
Pyleris Emmanouil, Koutsounas Ioannis S, Karantanos Panagiotis
机构信息
Department of Gastroenterology and Endoscopy Unit, Sismanogleion General Hospital, Marousi, Greece.
出版信息
Viszeralmedizin. 2014 Apr;30(2):136-9. doi: 10.1159/000360386.
BACKGROUND
Serrated polyposis syndrome (SPS) is a rare entity mainly concerning the 6th decade of life and which is characterized by the presence of multiple large hyperplastic polyps, sessile serrated adenomas, and adenomas within the colon.
CASE REPORT
We describe the case of a SPS patient with 3 synchronous adenocarcinomas. The morphologic features of serrated colorectal lesions, their characteristic molecular alterations, and their role in colorectal cancer development are discussed herein.
CONCLUSION
Our findings suggest that SPS is a rare condition with an increased risk for colon cancer. Patients suffering from SPS should have regular colonoscopic surveillance, and perhaps those with numerous dysplastic hyperplastic polyps should be treated with colectomy.
背景
锯齿状息肉病综合征（SPS）是一种罕见疾病，主要发生于60岁左右，其特征为结肠内存在多个大型增生性息肉、无蒂锯齿状腺瘤和腺瘤。
病例报告
我们描述了一名患有3处同时性腺癌的SPS患者的病例。本文讨论了锯齿状结直肠病变的形态学特征、其特征性分子改变及其在结直肠癌发生中的作用。
结论
我们的研究结果表明，SPS是一种罕见疾病，患结肠癌风险增加。患有SPS的患者应定期接受结肠镜监测，或许那些有大量发育异常增生性息肉的患者应接受结肠切除术治疗。
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