Improved Fmoc synthesis of bradykinin.
作者信息
Stephenson Rachel J, Plieger Paul G, Harding David R K
机构信息
IFS, Massey University, Palmerston North, New Zealand.
出版信息
Protein Pept Lett. 2011 Sep;18(9):952-5. doi: 10.2174/092986611796011509.
PMID:21443495
Abstract
Two arginine side-chain protecting groups, N(G)-4-methoxy-2,3,6-trimethylbenzensulfonyl group (Mtr) and N(G)-2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pmc), have been investigated at both the Arg(1) and/or Arg(9) position of the bioactive peptide, Bradykinin using Fluorenylmethyloxycarbonyl (Fmoc) Solid Phase Peptide Synthesis. A more efficient synthesis of the peptide has been found when a combination of Arg(Mtr) is present at position 1 and Arg(Pmc) is present at position 9 giving a cleaved pure yield of 52%.
摘要
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