Durand C M, Alonso C D, Subhawong A P, Kwiatkowski N P, Showel M, Carroll K C, Marr K A
Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Transpl Infect Dis. 2011 Aug;13(4):392-6. doi: 10.1111/j.1399-3062.2011.00601.x. Epub 2011 Mar 28.
Members of the genus Rhizopus within the class Zygomycetes can cause devastating opportunistic infections. Cutaneous disease arising from direct inoculation of fungal spores has the potential to disseminate widely. Here, we describe a dramatic case of cutaneous Rhizopus infection involving the penis in a patient with acute myelogenous leukemia. Despite aggressive surgical debridement, systemic antifungal therapy, and donor lymphocyte infusion, the infection was ultimately fatal. This case illustrates the unique diagnostic and therapeutic challenges in the clinical management of cutaneous Rhizopus infection.
接合菌纲中的根霉属成员可引起严重的机会性感染。由真菌孢子直接接种引起的皮肤疾病有可能广泛传播。在此，我们描述了一例急性髓系白血病患者阴茎发生皮肤根霉感染的显著病例。尽管进行了积极的手术清创、全身抗真菌治疗和供体淋巴细胞输注，但感染最终仍导致死亡。该病例说明了皮肤根霉感染临床管理中独特的诊断和治疗挑战。
