Department of Environmental Safety, Graduate School of Science and Engineering, Yamaguchi University, Ube, Japan.
Pediatr Diabetes. 2011 Aug;12(5):494-500. doi: 10.1111/j.1399-5448.2010.00727.x. Epub 2011 Mar 28.
The association between the fat mass- and obesity-associated (FTO) gene and a predisposition to obesity is inconsistent in adult Asian populations. We investigated the association of the FTO gene with weight status in Japanese children and adolescents.
DESIGN/SETTING: Nested case-control study and 3-yr longitudinal study - In the Shunan Child Cohort Study, fifth and eighth grade students attending all schools of Shunan completed the questionnaires. Overweight, including obesity, was defined as a percentage of overweight of 20% or in accordance with the International Obesity Task Force. We recruited 133 obese subjects and randomly selected controls from the 2006 cohort. We genotyped three FTO single nucleotide polymorphisms (SNPs): rs3751812, rs9939609, and rs1558902.
The three genotyped SNPs were in tight linkage disequilibrium, with the exception of one case. The minor SNP allele of rs3751812 conferred a predisposition to obesity, and its odds ratio was 2.2 [95% confidence interval (CI), 1.5-3.4] in the additive model and 2.7 (95% CI, 1.6-4.4) in the dominant model (p < 0.001). Although blood parameters and some lifestyle behaviors were significantly different between the cases and controls (p < 0.01), these traits were not significantly different among the genotypes. In addition, we did not find an association between the genotypes and body mass index change during the 3 yr.
The FTO gene is associated with the early onset of overweight in the Japanese population as well as in European populations. The results suggest that obesity-related risk factors in fifth and eighth graders appear because of their overweight status.
脂肪量和肥胖相关（FTO）基因与肥胖倾向之间的关联在亚洲成年人中不一致。我们研究了 FTO 基因与日本儿童和青少年体重状况的关系。
设计/设置：巢式病例对照研究和 3 年纵向研究-在顺南儿童队列研究中，所有顺南学校的五年级和八年级学生都完成了问卷。超重，包括肥胖，定义为超重 20%或按照国际肥胖工作组的标准。我们从 2006 年的队列中招募了 133 名肥胖受试者和随机选择的对照组。我们对三个 FTO 单核苷酸多态性（SNP）进行了基因分型：rs3751812、rs9939609 和 rs1558902。
除了一个病例外，三个基因分型的 SNP 紧密连锁不平衡。rs3751812 的次要 SNP 等位基因易患肥胖，其加性模型的优势比为 2.2（95%置信区间，1.5-3.4），显性模型为 2.7（95%置信区间，1.6-4.4）（p < 0.001）。尽管病例组和对照组之间的血液参数和一些生活方式行为有显著差异（p < 0.01），但这些特征在基因型之间没有显著差异。此外，我们没有发现基因型与 3 年内体重指数变化之间存在关联。
FTO 基因与日本人群以及欧洲人群的超重早期发病有关。结果表明，五年级和八年级学生的肥胖相关危险因素是由于他们的超重状态引起的。
