疟疾的间歇性预防治疗：青蒿琥酯和磺胺多辛-乙胺嘧啶组合的论据。
Intermittent preventive therapy for malaria: arguments in favour of artesunate and sulphamethoxypyrazine - pyrimethamine combination.
机构信息
ACT-ion Afrique, Brussels, Belgium.
出版信息
Malar J. 2011 Mar 29;10:70. doi: 10.1186/1475-2875-10-70.
Abstract
Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi.
摘要
最近的出版物对磺胺多辛-乙胺嘧啶（SP）在间歇性预防治疗儿童疟疾（IPTi）方面的无效性提出了严重警告。正在推荐其他疗法。通过使用不同的更好的磺胺类药物（磺胺二甲氧嘧啶），可以与青蒿琥酯和乙胺嘧啶制成固定剂量组合药丸。这种组合可以在 24 小时内完成完整的治疗（给药间隔为 12 小时）。建议在未来的 IPTi 现场研究中测试这种组合。
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