Bohn Desmond
Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2011;14(1):19-23. doi: 10.1053/j.pcsu.2011.01.002.
An accurate measurement of cardiac performance in infants after cardiopulmonary bypass has long been considered to be an important part of postoperative management. To be useful in clinical decision making, such measurements should ideally be reproducible, non invasive and accurately reflect tissue perfusion and oxygen delivery. Historically, we have relied on intermittent measurements of cardiac output using indicator dilution methods; and more recently, technologies that use pulse contour analysis, bio-impedance, or Doppler methodology. These all have the same shortcoming, that they provide a number that the information as to whether it provides adequate tissue perfusion. There is increasing emphasis being placed on the measurement of oxygen delivery either by mixed venous oxygen saturation and serum lactate, which are important markers of the adequacy of organ perfusion; and relating this to outcome, the development of organ dysfunction and length of ICU stay.
长期以来,准确测量体外循环后婴儿的心脏功能一直被视为术后管理的重要组成部分。为了在临床决策中发挥作用,理想情况下,此类测量应具有可重复性、非侵入性,并能准确反映组织灌注和氧输送情况。从历史上看,我们一直依赖于使用指示剂稀释法间歇性测量心输出量;最近,则依赖于使用脉搏轮廓分析、生物阻抗或多普勒方法的技术。这些方法都有同样的缺点,即它们提供的只是一个数字,而无法提供关于其是否能提供足够组织灌注的信息。目前越来越强调通过混合静脉血氧饱和度和血清乳酸来测量氧输送,这两者是器官灌注充足与否的重要指标;并将其与结果、器官功能障碍的发展以及重症监护病房(ICU)住院时间联系起来。