2 型糖尿病易感性单核苷酸多态性与多囊卵巢综合征无关。
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.
机构信息
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2538-41.e1-6. doi: 10.1016/j.fertnstert.2011.02.050. Epub 2011 Mar 27.
Abstract
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
摘要
研究了两组多囊卵巢综合征（PCOS）女性，一组包括 365 个家庭的 400 名先证者和患病姐妹，以及病例对照组包括 395 名 PCOS 患者和 171 名月经周期正常的健康女性，以确定在 2 型糖尿病全基因组关联研究中确定为易感基因座的单核苷酸多态性（SNP）是否也与 PCOS 相关。先前与 2 型糖尿病相关的 10 个基因中的 18 个等位变异均未发现与 PCOS 相关，但有些与β细胞功能指标相关。
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3
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