Emerson S S, Fleming T R
Epidemiology and Biometry Program, Arizona Cancer Center, Tucson.
Oncology (Williston Park). 1990 Mar;4(3):126-33; discussion 134, 136.
Clinical trials of new cancer treatments often involve multiple analyses of the data to address concerns related to medical ethics and the costs and efficiency of medical research. Failure to account for such interim analyses can introduce significant bias into the results of a study. The authors discuss the role of interim analyses in clinical trials and describe the factors that need to be considered in the planning, monitoring, and reporting of a study involving group sequential hypothesis tests.
新型癌症治疗方法的临床试验通常涉及对数据的多次分析，以解决与医学伦理以及医学研究的成本和效率相关的问题。未能考虑此类中期分析可能会给研究结果带来重大偏差。作者讨论了中期分析在临床试验中的作用，并描述了在涉及成组序贯假设检验的研究的规划、监测和报告中需要考虑的因素。
