Department of Medical Engineering and Biotechnology, University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745 Jena, Germany.
Ann Biomed Eng. 2011 Jul;39(7):1972-83. doi: 10.1007/s10439-011-0294-5. Epub 2011 Mar 29.
Patients suffering from schizophrenia have an increased mortality risk due to cardiovascular events. Recently the analysis of peripheral circulation has revealed interesting results in the study of vascular pathological conditions assuming that the state of microcirculation of the skin is at least partly representative for the constitution of other vascular beds including those of the cardiac muscle and arteries. The objective of this study was to investigate the microcirculation in patients with acute schizophrenia (PAT, n = 15, mean age 33.0 years, 7 male, 8 female) to identify whether spectral features from blood flow signals derived through laser Doppler spectrometry are significantly altered compared to healthy subjects (CON, n = 15, mean age 32.4 years, 7 male, 8 female) by means of the post-occlusive reactive hyperemia test. It was also explored if a segmentation of the post-ischemic stage can disclose more detailed and additional information about the dynamic behavior of the blood flow during hyperemic response. For this reason, time-frequency analyses were performed to observe the course of the blood flow frequency components over time. Our results indicate significant differences in the patients group, already detectable under baseline conditions but also in the hyperemic phase. The main modifications affect the respiratory (p = 0.006) as well as the cardiac (p = 0.001) activity. It was further shown that the application of a segmented analysis of the post-ischemic state considerably improves the differentiation between both groups. Only with the introduced segmentation algorithm using a window length of 2048 samples and a shift of 128 and 256 samples we could demonstrate influences of the disease on the endothelial (p = 0.029), the sympathetic (p = 0.019) and the myogenic (p = 0.029) mechanisms. These information provide further insights into the appearance of schizophrenia and could lead to an improvement of the patients' treatment to avoid the occurrence of cardiovascular events.
患有精神分裂症的患者由于心血管事件而死亡的风险增加。最近，对周围循环的分析在研究血管病理状况方面取得了有趣的结果，假设皮肤微循环的状态至少在一定程度上代表了其他血管床的状态，包括心肌和动脉。本研究的目的是研究急性精神分裂症患者（PAT，n = 15，平均年龄 33.0 岁，7 男，8 女）的微循环，以确定通过激光多普勒光谱法获得的血流信号的光谱特征是否与健康受试者（CON，n = 15，平均年龄 32.4 岁，7 男，8 女）相比有显著改变通过闭塞后反应性充血试验。还探讨了缺血后阶段的分割是否可以揭示更多关于充血反应期间血流动态行为的详细和附加信息。为此，进行了时频分析以观察血流频率成分随时间的变化过程。我们的结果表明，在患者组中存在显著差异，这些差异在基线条件下已经可以检测到，并且在充血期也可以检测到。主要的改变影响呼吸（p = 0.006）和心脏（p = 0.001）活动。进一步表明，对缺血后状态的分段分析的应用可以极大地改善两组之间的区分。只有通过应用引入的使用 2048 个样本的窗口长度和 128 和 256 个样本的移位的分段分析算法，我们才能证明疾病对内皮（p = 0.029），交感神经（p = 0.019）和肌源性（p = 0.029）机制的影响。这些信息提供了对精神分裂症表现的进一步了解，并可能导致改善患者的治疗以避免心血管事件的发生。
