Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Magn Reson Med. 2011 Oct;66(4):945-9. doi: 10.1002/mrm.22923. Epub 2011 Mar 28.
Lithium (Li) is a core for many neuropsychiatric conditions. The safe serum range of Li treatment is narrow, and regular monitoring by blood test is required, although serum levels are thought to be a poor indicator of Li concentration in the brain itself. Brain Li concentration can be measured by magnetic resonance spectroscopy. However, little data exist in the healthy human brain, and there are no studies of the relaxation properties of brain (7)Li at 3 T. Here, 11 healthy male subjects were prescribed Li over a period of 11 days. In seven subjects, the in vivo T(1) of (7)Li was measured to be 2.1 ± 0.7 s. In the remaining subjects, spectroscopic imaging (1D) yielded a mean brain (7)Li concentration of 0.71 ± 0.1 mM, with no significant difference between gray and white matter. Mean serum concentration was 0.9 ± 0.16 mM, giving a mean brain/serum ratio of 0.78 ± 0.26.
锂（Li）是许多神经精神疾病的核心元素。Li 的治疗安全血清范围很窄，需要定期通过血液检查进行监测，尽管人们认为血清水平是大脑中 Li 浓度的一个很差的指标。可以通过磁共振波谱测量脑 Li 浓度。然而，在健康人的大脑中几乎没有数据，并且没有关于 3 T 下脑（7）Li 弛豫特性的研究。在这里，11 名健康男性受试者在 11 天内服用 Li。在 7 名受试者中，测量到（7）Li 的体内 T（1）为 2.1 ± 0.7 s。在其余受试者中，光谱成像（1D）得出脑（7）Li 的平均浓度为 0.71 ± 0.1 mM，灰质和白质之间没有显著差异。平均血清浓度为 0.9 ± 0.16 mM，得出脑/血清比为 0.78 ± 0.26。
