仿生全合成利德那螺酮 A 和双利德那螺酮及其生物合成途径的修订。

Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways.

机构信息

Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, China 518055.

出版信息

Org Lett. 2011 May 6;13(9):2192-5. doi: 10.1021/ol200418e. Epub 2011 Mar 29.

DOI:10.1021/ol200418e

PMID:21446662

Abstract

Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl linderone, leading to efficient biomimetic total syntheses of linderaspirone A and bi-linderone, two recently discovered bioactive spirocyclopentenedione natural products.

摘要

简单的阳光暴露足以引发天然甲基利德酮中的光化学[2+2]环加成-科普或自由基重排级联反应，从而有效地模拟生物合成了利德螺酮 A 和双利德酮，这两种最近发现的具有生物活性的螺环戊二酮天然产物。