Chen Lin, Liu Bo, Deng Jun-Jie, Zhang Jun-Sheng, Li Wei, Ahmed Abrar, Yin Sheng, Tang Gui-Hua
School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou Guangdong 510006 China
The Second Clinical Medical College, Guangzhou University of Chinese Medicine Guangzhou 510006 China.
RSC Adv. 2018 May 16;8(32):17898-17904. doi: 10.1039/c8ra03094d. eCollection 2018 May 14.
Chromatographic fractionation of the roots of has led to the isolation of three new monomers of cyclopentenedione derivatives (1-3), a pair of new enantiomers of bi-linderone derivatives (4a/4b), and six known cyclopentenediones (5-8 and 9a/9b). Their structures were determined by NMR and MS data. The absolute configurations of the new bi-linderone derivative enantiomers (4a/4b) were determined by ECD calculation. (±)-Lindepentone A (1) presents the novel skeleton of 3,5-dioxocyclopent-1-enecarboxylate. Lindoxepines A (2) and B (3) present an unprecedented oxepine-2,5-dione derivative skeleton, which may be enlightening for the biosynthesis of the monomers of cyclopentenediones. A possible biosynthetic pathway for 1 and a plausible biosynthetic pathway from stilbenes to cyclopentenediones the key intermediates 2 and 3 were postulated. The inhibitory activity of these compounds against three microorganisms was also evaluated.
对[植物名称]根进行色谱分离，得到了三种新的环戊二烯酮衍生物单体（1 - 3）、一对新的双环二酮衍生物对映体（4a/4b）以及六种已知的环戊二烯酮（5 - 8和9a/9b）。它们的结构通过核磁共振（NMR）和质谱（MS）数据确定。新的双环二酮衍生物对映体（4a/4b）的绝对构型通过电子圆二色光谱（ECD）计算确定。（±）-林德戊酮A（1）呈现出3,5 - 二氧代环戊 - 1 - 烯羧酸酯的新颖骨架。林德恶嗪A（2）和B（3）呈现出前所未有的恶嗪 - 2,5 - 二酮衍生物骨架，这可能为环戊二烯酮单体的生物合成提供启示。推测了1的可能生物合成途径以及从芪类化合物到环戊二烯酮关键中间体2和3的合理生物合成途径。还评估了这些化合物对三种微生物的抑制活性。
