电化学和 SPR 监测金属硫蛋白的金属释放和螯合。

Metal release from and sequestration by metallothioneins monitored by electrochemistry and SPR.

机构信息

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, People's Republic of China.

出版信息

Curr Pharm Biotechnol. 2011 May;12(5):847-52. doi: 10.2174/138920111795470886.

DOI:10.2174/138920111795470886

PMID:21446906

Abstract

Due to the high affinity of metallothioneins (MTs) toward various transition metal ions, MTs play an important role in regulation of essential metals, detoxification of heavy metals, and scavenging of free radicals. In this review, we focus on the recent development on the metal release from and sequestration by MTs characterized by electrochemistry and surface plasmon resonance (SPR). The investigation of metal release and coordination processes is of great significance in illustrating the intriguing role of MTs in environmental toxicology.

摘要

由于金属硫蛋白（MTs）对各种过渡金属离子具有高亲和力，因此 MTs 在调节必需金属、解毒重金属和清除自由基方面发挥着重要作用。在这篇综述中，我们重点介绍了通过电化学和表面等离子体共振（SPR）来描述 MTs 的金属释放和螯合作用的最新研究进展。研究金属释放和配位过程对于阐明 MTs 在环境毒理学中的作用具有重要意义。