促肾上腺皮质激素刺激脂肪细胞中脂解作用时环磷酸腺苷与蛋白激酶活性的相关性：腺苷脱氨酶和放线菌素D的影响
The correlation of cyclic AMP and protein kinase activity in adipocytes with lipolysis stimulated by ACTH: the effect of adenosine deaminase and actinomycin D.
作者信息
Wong E H, Loten E G, Park C R
出版信息
J Cyclic Nucleotide Res. 1978 Oct;4(5):359-74.
ACTH at levels as low as 0.05 mU/ml stimulated lipolysis, protein kinase and cyclic AMP accumulation in isolated fat cells from fed and fasted rats. Changes in cyclic AMP levels and in the protein kinase activity ratio were well correlated temporally. The protein kinase activity ratio was potentiated by adenosine deaminase. A sudden increase or decrease in either ACTH or dibutyryl cyclic AMP concentration was associated with a rapid and corresponding change in the rate of glycerol production. With ACTH, the changes in glycerol production were accompanied by appropriate changes in cyclic AMP levels. Actinomycin-D (10 UM) did not affect lipolysis or cyclic AMP accumulation activated by ACTH in fat cells.
低至0.05 mU/ml的促肾上腺皮质激素（ACTH）可刺激喂食和禁食大鼠分离脂肪细胞中的脂肪分解、蛋白激酶和环磷酸腺苷（cAMP）积累。环磷酸腺苷水平和蛋白激酶活性比值的变化在时间上具有良好的相关性。腺苷脱氨酶可增强蛋白激酶活性比值。促肾上腺皮质激素或二丁酰环磷酸腺苷浓度的突然升高或降低与甘油生成速率的快速相应变化相关。对于促肾上腺皮质激素，甘油生成的变化伴随着环磷酸腺苷水平的相应变化。放线菌素-D（10 μM）不影响促肾上腺皮质激素激活的脂肪细胞中的脂肪分解或环磷酸腺苷积累。
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