Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):1108-11. doi: 10.1016/j.pnpbp.2011.03.010. Epub 2011 Apr 3.
Both environmental and genetic factors have been reported to be involved in suicidal behaviors. Considerable evidence indicates that impulsive aggression is one of the important risk factors that contribute to suicide. A recent study has shown that prostaglandin E2 type 1 receptor (EP1) signaling regulates impulsive-aggressive behaviors in mice under both social and environmental stresses. To test the possible involvement of the EP1 gene in suicide, we carried out an association study of EP1 gene polymorphisms with suicide completers in the Japanese population.
We studied 5 SNPs including one SNP in exon 2 (rs3745459) and four SNPs in the potential promoter region of the EP1 gene (rs3810255, rs3810254, rs3810253 and rs10416814) in 374 healthy control and 287 completed suicide victims using standard Taqman probe genotyping assays.
No significant differences of the genotypic distribution, allelic frequency or haplotype distribution between controls and suicide completers were found. Gender based analysis revealed that genotypic, allelic and haplotypic distributions of rs3810255, rs3810254, rs3810253 and rs10416814 SNPs were significantly different between the female control and female suicide groups, although the differences did not withstand correction for multiple comparisons.
We could not find an association of EP1 gene with suicide in the Japanese population. Because several SNPs in the promoter region of the EP1 gene were nominally significantly associated with suicide in the female, further studies with a larger sample size and different population are needed to confirm this result.
环境和遗传因素都被报道与自杀行为有关。大量证据表明冲动性攻击是导致自杀的重要危险因素之一。最近的一项研究表明，前列腺素 E2 型 1 受体 (EP1) 信号在社交和环境压力下调节小鼠的冲动攻击行为。为了测试 EP1 基因是否与自杀有关，我们在日本人群中进行了 EP1 基因多态性与自杀完成者的关联研究。
我们使用标准 Taqman 探针基因分型检测方法研究了包括外显子 2 中的一个 SNP(rs3745459)和 EP1 基因潜在启动子区域中的四个 SNP(rs3810255、rs3810254、rs3810253 和 rs10416814)在内的 5 个 SNP，共纳入 374 名健康对照和 287 名自杀完成者。
在对照组和自杀完成者之间，基因型分布、等位基因频率或单倍型分布没有显著差异。基于性别的分析表明，rs3810255、rs3810254、rs3810253 和 rs10416814 SNP 的基因型、等位基因和单倍型分布在女性对照组和女性自杀组之间存在显著差异，尽管这些差异在经过多次比较校正后并不显著。
我们在日本人群中没有发现 EP1 基因与自杀的关联。由于 EP1 基因启动子区域的几个 SNP 与女性自杀存在显著关联，需要进一步的研究来证实这一结果。
