Barak M, Steiner M, Finkel B, Abrahamson J, Antal S, Gruener N
Biochemistry Department, Lady Davis Carmel Hospital, Haifa, Israel.
Eur J Cancer. 1990;26(5):577-80. doi: 10.1016/0277-5379(90)90081-4.
Serum concentrations of CA-15.3, tissue polypeptide antigen (TPA) and mucinous-like carcinoma-associated antigen (MCA) were measured in 327 women: 81 controls, 93 patients with benign breast disease, 46 patients recently diagnosed with breast cancer and 107 patients during breast cancer follow-up. CA-15.3 was elevated in 16% of the controls, in 29% of the patients with benign breast disease, in 65% of the breast cancer patients and in 74% of the follow-up patients. TPA was elevated in 4%, 11%, 36% and 75%, respectively. The corresponding figures for MCA were 10%, 8%, 30% and 64%. The highest sensitivity for cancer detection (74%) was obtained with a combination of CA-15.3 and TPA, while the specificity of this panel was 75%. The negative predictive value of these combined tests was 93%. MCA scored lower values, being only 30% sensitive. The CA-15.3/TPA panel may increase sensitivity compared with single marker tests and provide additional information for clinical evaluation.
对327名女性检测了血清CA-15.3、组织多肽抗原（TPA）和黏液样癌相关抗原（MCA）的浓度：81名对照者、93名患有良性乳腺疾病的患者、46名近期诊断为乳腺癌的患者以及107名处于乳腺癌随访期的患者。CA-15.3在16%的对照者、29%的良性乳腺疾病患者、65%的乳腺癌患者以及74%的随访患者中升高。TPA分别在4%、11%、36%和75%的人群中升高。MCA的相应数据分别为10%、8%、30%和64%。CA-15.3和TPA联合检测对癌症检测的敏感性最高（74%），而该组合的特异性为75%。这些联合检测的阴性预测值为93%。MCA的数值较低，敏感性仅为30%。与单一标志物检测相比，CA-15.3/TPA组合可能会提高敏感性，并为临床评估提供额外信息。
