丝裂霉素A与托芬那酸联合治疗胰腺癌可促进Sp1降解及协同抗肿瘤活性——信函 - Suppr

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Combined treatment of pancreatic cancer with mithramycin a and tolfenamic Acid promotes sp1 degradation and synergistic antitumor activity--letter.

作者信息

Chou Ting-Chao

出版信息

Cancer Res. 2011 Apr 1;71(7):2793; discussion 2794-800. doi: 10.1158/0008-5472.CAN-11-0379. Epub 2011 Mar 29.

DOI:10.1158/0008-5472.CAN-11-0379

PMID:21447740

Abstract

摘要

相似文献

Combined treatment of pancreatic cancer with mithramycin a and tolfenamic Acid promotes sp1 degradation and synergistic antitumor activity--letter.丝裂霉素A与托芬那酸联合治疗胰腺癌可促进Sp1降解及协同抗肿瘤活性——信函

Cancer Res. 2011 Apr 1;71(7):2793; discussion 2794-800. doi: 10.1158/0008-5472.CAN-11-0379. Epub 2011 Mar 29.

Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.米托蒽醌 A 和托芬那酸联合治疗胰腺癌可促进 Sp1 降解和协同抗肿瘤活性。

Cancer Res. 2010 Feb 1;70(3):1111-9. doi: 10.1158/0008-5472.CAN-09-3282. Epub 2010 Jan 19.

Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.托芬那酸与胰腺癌生长、血管生成及Sp蛋白降解

J Natl Cancer Inst. 2006 Jun 21;98(12):855-68. doi: 10.1093/jnci/djj232.

Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.桦木酸和米托蒽醌联合有效抑制增殖、侵袭和血管生成抑制胰腺癌。

Cancer Res. 2011 Aug 1;71(15):5182-93. doi: 10.1158/0008-5472.CAN-10-2016. Epub 2011 Jun 14.

Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.贝伐单抗与光辉霉素A协同抗血管生成活性的分子基础

Cancer Res. 2007 May 15;67(10):4878-85. doi: 10.1158/0008-5472.CAN-06-3494.

Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.光神霉素a对生长中的肿瘤中Sp1表达的治疗性抑制与对人类胰腺癌的强效抗血管生成作用直接相关。

Cancer. 2007 Dec 15;110(12):2682-90. doi: 10.1002/cncr.23092.

Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites.光神霉素A通过Sp1位点下调XIAP基因启动子，使癌细胞对TRAIL介导的凋亡敏感。

Mol Cancer Ther. 2006 Nov;5(11):2737-46. doi: 10.1158/1535-7163.MCT-06-0426.

Transcription factor Sp1 is upregulated by PKCι to drive the expression of YAP1 during pancreatic carcinogenesis.转录因子 Sp1 被 PKCι 上调，以在胰腺癌发生过程中驱动 YAP1 的表达。

Carcinogenesis. 2021 Apr 17;42(3):344-356. doi: 10.1093/carcin/bgaa113.

Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution.小分子托芬那酸和膳食香料姜黄素治疗通过抑制 Sp1、破坏 NF-κB 向核内易位和细胞周期相分布，增强胰腺癌细胞的抗增殖作用。

J Nutr Biochem. 2016 May;31:77-87. doi: 10.1016/j.jnutbio.2016.01.003. Epub 2016 Feb 10.

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth.使用托芬那酸靶向特异性蛋白1转录因子和生存素以抑制尤因肉瘤细胞生长。

Invest New Drugs. 2017 Apr;35(2):158-165. doi: 10.1007/s10637-016-0417-9. Epub 2016 Dec 26.

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