Miyakoshi Naohisa
Department of Orthopedic Surgery, Akita University Graduate School of Medicine.
Clin Calcium. 2011 Apr;21(4):575-81.
Parathyroid hormone (PTH) is a major hormonal regulator of calcium homeostasis. Continuous exposure of bone to PTH results in a net catabolic or resorptive response, whereas intermittent exposure to PTH leads to dramatic increases in bone formation and bone volume. Anabolic effects of PTH on bone have been demonstrated histologically in osteopenic animal models and in human osteoporosis. PTH increases the size of remodeling space and the number of basic multicellular units, resulting in a positive bone balance. PTH treatment also induces modeling bone formation at quiescent surfaces. PTH can increase and re-establish trabecular connectivity with a shift toward a more plate-like structure.
甲状旁腺激素（PTH）是钙稳态的主要激素调节因子。骨骼持续暴露于PTH会导致净分解代谢或吸收反应，而间歇性暴露于PTH会导致骨形成和骨量显著增加。PTH对骨骼的合成代谢作用已在骨质减少动物模型和人类骨质疏松症中得到组织学证实。PTH增加了重塑空间的大小和基本多细胞单位的数量，从而导致正性骨平衡。PTH治疗还可在静止表面诱导成骨。PTH可以增加并重新建立小梁连接，并向更板状的结构转变。
