Department of Pediatric Gastroenterology, Stanford University Medical Center, Lucile Packard Children's Hospital, 750 Welch Road, Palo Alto, CA 94304, USA.
J Perinatol. 2011 Apr;31 Suppl 1:S57-60. doi: 10.1038/jp.2010.182.
Parenteral nutrition (PN), containing fat emulsions derived from soybean, has been implicated in the progression of PN-associated liver disease and cholestasis, particularly in infants with short bowel syndrome. Clinical use of Omegaven, a parenteral fish-oil emulsion, has been shown in recent studies to be a promising therapy to reverse liver disease and cholestasis. This review summarizes the rationale, relevant clinical investigations and future direction of Omegaven therapy for PN-dependent infants.
肠外营养(PN)含有源自大豆的脂肪乳剂,已被认为与 PN 相关肝病和胆汁淤积有关,特别是在短肠综合征的婴儿中。最近的研究表明,临床使用一种肠外鱼油乳剂——欧玛佳,是一种有前途的治疗方法,可以逆转肝病和胆汁淤积。本文综述了欧玛佳治疗 PN 依赖婴儿的原理、相关临床研究和未来方向。