National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD, USA.
Cell Mol Neurobiol. 2011 Aug;31(6):809-13. doi: 10.1007/s10571-011-9677-2. Epub 2011 Mar 29.
Marshall Nirenberg will always be remembered for deciphering the genetic code by which DNA and RNA sequences specify the amino acid sequence in proteins. His switch to neurobiology in the 1960s was driven, in part, by an interest in the possibility of a neural code specifying the development and functioning of the neural circuits that underlie brain function. Neural cell adhesion or recognition molecules would probably be involved in such circuit formation, and this review briefly examines one set of such molecules. The specific binding between presynaptic neurexins and postsynaptic neuroligins could constitute one aspect of the code underlying the formation of specific synaptic circuits.
马歇尔·尼伦伯格将因破解 DNA 和 RNA 序列指定蛋白质中氨基酸序列的遗传密码而被永远铭记。他在 20 世纪 60 年代转向神经生物学部分是因为对神经代码指定构成大脑功能基础的神经回路的发育和功能的可能性感兴趣。神经细胞粘附或识别分子可能参与这种电路形成，本综述简要检查了其中一组分子。突触前神经蛋白与突触后神经黏附素之间的特异性结合可以构成特定突触回路形成的代码的一个方面。
