Department of Neurosurgery, Third Military Medical University, Chongqing, People's Republic of China.
J Magn Reson Imaging. 2011 Apr;33(4):817-21. doi: 10.1002/jmri.22416.
To determine the regional changes in the shapes of subcortical structures in idiopathic generalized epilepsy using a vertex-based analysis method. Earlier studies found that gray matter volume in the frontal, parietal, and temporal lobes is significantly altered in idiopathic generalized epilepsy (IGE). Research has indicated that a relationship exists between the brain's subcortical structures and epilepsy. However, little is known about possible changes in the subcortical structures in IGE.
This study aims to determine the changes in the shape of subcortical structures in IGE using vertex analysis. Fourteen male patients with IGE and 28 age- and sex-matched healthy controls were included in this study, which used high-resolution magnetic resonance imaging. We performed a vertex-based shape analysis, in which we compared patients with IGE with the controls, on the subcortical structures that we had obtained from the MRI data.
Statistical analysis showed significant regional atrophy in the left thalamus, left putamen and bilateral globus pallidus in patients with IGE.
These results indicate that regional atrophy of the basal ganglia and the thalamus may be related to seizure disorder. In the future, these findings may prove useful for choosing new therapeutic regimens.
使用基于顶点的分析方法，确定特发性全面性癫痫患者皮质下结构的形状的区域性变化。早期研究发现，特发性全面性癫痫（IGE）患者的额叶、顶叶和颞叶的灰质体积明显改变。研究表明，大脑皮质下结构与癫痫之间存在关系。然而，关于 IGE 中皮质下结构的可能变化知之甚少。
本研究旨在使用顶点分析来确定 IGE 患者皮质下结构的形状变化。该研究纳入了 14 名男性 IGE 患者和 28 名年龄和性别匹配的健康对照者，使用高分辨率磁共振成像。我们对从 MRI 数据中获得的皮质下结构进行了基于顶点的形状分析，比较了 IGE 患者和对照组。
统计分析显示，IGE 患者的左侧丘脑、左侧壳核和双侧苍白球存在明显的区域性萎缩。
这些结果表明，基底节和丘脑的区域性萎缩可能与癫痫发作有关。未来，这些发现可能有助于选择新的治疗方案。
