Oddsson Saemundur J, Sigurjonsson Hannes, Helgadottir Solveig, Sigurdsson Martin I, Viktorsson Sindri Aron, Arnorsson Thorarinn, Gudbjartsson Tomas
Hjarta- og, lungnaskurðdeild, Landspítala.
Laeknabladid. 2011 Apr;97(4):223-8. doi: 10.17992/lbl.2011.04.362.
Obesity has been related to increased postoperative morbidity and mortality following open-heart surgery. However, recent studies have shown no association or even a more favourable outcome in obese patients. This relationship was investigated in a well-defined cohort of patients that underwent myocardial revascularisation in Iceland.
A retrospective study including all patients that underwent isolated myocardial revascularisation in Iceland from 2002 to 2006. Altogether 720 patients were divided into two groups, an obese group, with BMI >30 kg/m2 (n=207, 29%), and a non-obese group with BMI ≤30 kg/m2 (n=513, 71%). Patient demographics, complications, operative mortality and long term survival of both groups were compared.
Demographics were comparable between the groups. Obese patients were 2.4 years younger, more likely to use statins (83,3% vs. 71,2%, had a significantly lower EuroSCORE (4.3 vs. 5.0) but a slightly longer operation time. Pleural fluid was less often drained in obese patients (8.2 vs. 15.0%) but rates for other complications were similar in both groups, as was operative mortality ≤30 days (2.0% vs. 3.7%), 1 and 5 year survival. In a multivariate analysis obesity was not an independent risk factor for minor or major complications, operative mortality or long term survival.
The rate of complications and operative mortality after myocardial revascularisation is not significantly higher in obese patients and the same applies to long term survival. This is true even after correcting for confounding factors in a multivariate analysis.
肥胖与心脏直视手术后术后发病率和死亡率增加有关。然而,最近的研究表明肥胖患者并无关联,甚至有更有利的结果。在冰岛一组明确的接受心肌血运重建的患者中对这种关系进行了调查。
一项回顾性研究,纳入了2002年至2006年在冰岛接受单纯心肌血运重建的所有患者。总共720名患者分为两组,肥胖组,BMI>30 kg/m²(n=207,29%),非肥胖组BMI≤30 kg/m²(n=513,71%)。比较了两组患者的人口统计学、并发症、手术死亡率和长期生存率。
两组之间的人口统计学特征具有可比性。肥胖患者年轻2.4岁,更有可能使用他汀类药物(83.3%对71.2%),欧洲心脏手术风险评估系统(EuroSCORE)显著更低(4.3对5.0),但手术时间略长。肥胖患者胸腔积液引流较少(8.2%对15.0%),但两组其他并发症发生率相似,30天内手术死亡率(2.0%对3.7%)、1年和5年生存率也相似。在多变量分析中,肥胖不是轻微或严重并发症、手术死亡率或长期生存的独立危险因素。
肥胖患者心肌血运重建后的并发症发生率和手术死亡率并不显著更高,长期生存情况也是如此。即使在多变量分析中校正混杂因素后也是如此。