Medical Physics Department, Santa Maria Nuova Hospital, Reggio Emilia, Italy.
Health Phys. 2011 May;100(5):515-22. doi: 10.1097/HP.0b013e3182092732.
Targeted radionuclide therapies in nuclear medicine departments increasingly depend on using unsealed beta radiation sources in the labeling of peptides and antibodies. Monitoring doses received by the fingers and hands during these procedures is best accomplished with TLD dosimeters that can be located at the fingertips. The present study examines the response of two TLD dosimeters (MCP-Ns and GR200A) to 90Sr/90Y, 85Kr, and 147Pm. The dosimeters were supplied by two different services, and all irradiations were performed at the PTB Institute in Germany. Each dosimetry service evaluated the dosimeters without knowledge that they had been purposefully irradiated. The accuracy and precision of the dosimeters were evaluated as a function of delivered dose, energy of beta particles and angular incidence. The results are compared to performance measures recommended by the IEC. Both dosimeter types displayed significant energy dependence. Angular dependence was moderate. Accuracy and precision as a function of dose (linearity) differed between the two systems, with the MCP-Ns being noticeably better than the GR200A. The superior precision makes the MCP-Ns much more useful for extremity dose measurements. The differences between these two dosimeter systems reinforce the need to evaluate a dosimeter carefully before using it in the daily work routine.
核医学部门的靶向放射性核素治疗越来越依赖于在肽和抗体的标记中使用未密封的β射线源。在这些程序中,通过位于指尖的 TLD 剂量计可以最好地监测手指和手部接收到的剂量。本研究检查了两种 TLD 剂量计(MCP-Ns 和 GR200A)对 90Sr/90Y、85Kr 和 147Pm 的响应。这些剂量计由两个不同的服务提供,所有辐照均在德国 PTB 研究所进行。每个剂量计服务在不知道它们已被有意辐照的情况下评估剂量计。根据传递剂量、β粒子能量和入射角评估剂量计的准确性和精密度。结果与 IEC 推荐的性能指标进行了比较。两种剂量计类型均表现出显著的能量依赖性。角依赖性适中。两种系统的剂量(线性)作为剂量的函数的准确性和精密度不同,MCP-Ns 明显优于 GR200A。优越的精度使 MCP-Ns 更适合用于四肢剂量测量。这两种剂量计系统之间的差异强调了在将其用于日常工作常规之前仔细评估剂量计的必要性。