雄性小鼠性刺激后磷酸化丝裂原活化蛋白激酶的快速激活。
Rapid activation of phosphorylated mitogen-activated protein kinase after sexual stimulation in male mice.
作者信息
Taziaux Mélanie, Keller Matthieu, Balthazart Jacques, Bakker Julie
机构信息
Research Group in Behavioral Neuroendocrinology, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
出版信息
Neuroreport. 2011 Apr 20;22(6):294-8. doi: 10.1097/WNR.0b013e3283460f35.
Abstract
We mapped cells immunoreactive for the phosphorylated form (p44/p42) of the mitogen-activated protein kinase (pMAPK--also known as ERK1/2) in the brain of male mice after exposure to female olfactory cues or after the display of male copulatory behaviors. Exposure to soiled bedding from estrous females or the display of coital behaviors rapidly (within 10 min) induced MAPK phosphorylation in most of the brain regions known to be involved in the processing of olfactory cues (main and accessory olfactory bulbs, amygdala, and medial preoptic area) and in the control of copulatory behavior (amygdala and medial preoptic area). MAPK phosphorylation thus seems to be a useful marker to study short-term neural activation associated with the expression of specific behaviors.
摘要
我们绘制了雄性小鼠在暴露于雌性嗅觉线索后或表现出雄性交配行为后，其大脑中对有丝分裂原活化蛋白激酶（pMAPK，也称为ERK1/2）的磷酸化形式（p44/p42）具有免疫反应性的细胞分布图。暴露于发情期雌性的脏垫料或交配行为的表现会迅速（在10分钟内）诱导大多数已知参与嗅觉线索处理（主嗅球和副嗅球、杏仁核和内侧视前区）以及交配行为控制（杏仁核和内侧视前区）的脑区中的MAPK磷酸化。因此，MAPK磷酸化似乎是研究与特定行为表达相关的短期神经激活的有用标志物。
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