喷他脒类似物1：顺式和反式丁脒类似物作为抗卡氏肺孢子虫肺炎药物的合成
Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.
作者信息
Donkor Isaac O, Jones Susan K, Tidwell Richard R
机构信息
College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125.
出版信息
Bioorg Med Chem Lett. 1993;3(6):1137-1140. doi: 10.1016/S0960-894X(00)80302-9.
Abstract
Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.
摘要
已合成在双脒基苯基或双咪唑啉基苯基官能团之间的醚桥中具有不饱和键的布他米定类似物，作为喷他脒的半刚性类似物。这些化合物在该疾病的大鼠模型中表现出良好的抗卡氏肺孢子虫肺炎活性。
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