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Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.喷他脒类似物1：顺式和反式丁脒类似物作为抗卡氏肺孢子虫肺炎药物的合成
Bioorg Med Chem Lett. 1993;3(6):1137-1140. doi: 10.1016/S0960-894X(00)80302-9.
2
Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.抗卡氏肺孢子虫肺炎药物喷他脒的顺式和反式丁脒类似物与DNA的序列选择性结合。
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本文引用的文献

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Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group.卡氏肺孢子虫肺炎治疗评估。PCP治疗项目组。
Am J Med. 1984 Mar;76(3):501-8. doi: 10.1016/0002-9343(84)90670-3.
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Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者对甲氧苄啶-磺胺甲恶唑的不良反应。
Ann Intern Med. 1984 Apr;100(4):495-9. doi: 10.7326/0003-4819-100-4-495.
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The effects of antimicrobial agents on ribonucleic acid polymerase.抗菌剂对核糖核酸聚合酶的影响。
Mol Pharmacol. 1965 Jul;1(1):1-13.
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Latent Pneumocystis infection of rats, relapse, and chemotherapy.大鼠的潜伏性肺孢子菌感染、复发及化疗
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Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin.
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Update: acquired immunodeficiency syndrome--United States.最新消息：获得性免疫缺陷综合征——美国
MMWR Morb Mortal Wkly Rep. 1985 May 10;34(18):245-8.
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Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.阳离子抗锥虫药及其他抗菌药物在实验性卡氏肺孢子虫肺炎治疗中的应用
Antimicrob Agents Chemother. 1988 Jun;32(6):896-905. doi: 10.1128/AAC.32.6.896.
8
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.1,5-双（4-脒基苯氧基）戊烷（喷他脒）类似物在实验性卡氏肺孢子虫肺炎治疗中的应用
J Med Chem. 1990 Apr;33(4):1252-7. doi: 10.1021/jm00166a026.
9
Polyamine metabolism in Pneumocystis carinii.卡氏肺孢子虫中的多胺代谢
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New aromatic diamidines with central alpha-oxyalkane or alpha, omega-dioxyalkane chains. Structure-activity relationships for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation process.
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喷他脒类似物1：顺式和反式丁脒类似物作为抗卡氏肺孢子虫肺炎药物的合成

Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.

作者信息

Donkor Isaac O, Jones Susan K, Tidwell Richard R

机构信息

College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125.

出版信息

Bioorg Med Chem Lett. 1993;3(6):1137-1140. doi: 10.1016/S0960-894X(00)80302-9.

DOI:10.1016/S0960-894X(00)80302-9
PMID:21451734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3065065/
Abstract

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.

摘要

已合成在双脒基苯基或双咪唑啉基苯基官能团之间的醚桥中具有不饱和键的布他米定类似物，作为喷他脒的半刚性类似物。这些化合物在该疾病的大鼠模型中表现出良好的抗卡氏肺孢子虫肺炎活性。