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用于去磷酸化中毒的人乙酰胆碱酯酶的首个高效非离子型重活化剂。

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

机构信息

CNRS UMR 6014-COBRA & FR 3038, IRCOF, Rue Lucien Tesnière, 76821 Mont Saint Aignan, France.

出版信息

Chem Commun (Camb). 2011 May 14;47(18):5295-7. doi: 10.1039/c1cc10787a. Epub 2011 Mar 31.

DOI:10.1039/c1cc10787a
PMID:21451868
Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

摘要

神经毒剂是具有强烈抑制乙酰胆碱酯酶（AChE）能力的高毒性有机磷化合物。在此，我们描述了两种新型非带电重活化剂，它们对中毒的人 AChE 的重活化能力与 HI-6、Obidoxime、TMB-4 和 HLö-7 相当或更优。

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