[T cell receptor BV gene preferential usage in oral lichen planus].

PURPOSE

To identify the T cell receptor (TCR) structural characteristics of infiltrating T cells derived from the lesional tissues of oral lichen planus (OLP) patients.

METHODS

BV gene distribution analysis was performed quantitatively in OLP patients using real-time polymerase chain reaction. The data was analyzed by Mann-Whitney U test using GraphPad Prism version 5.00 software.

RESULTS

The usage toward BV4, BV14 and BV18 in the lesional tissues from 43 OLP patients was significantly higher than the usage toward these BV genes in the peripheral blood from 39 OLP patients.

CONCLUSION

Infiltrating T cells derived from the lesional tissues in a cohort of Chinese OLP patients display preferential usage toward BV4, BV14 and BV18. It indicates that the T cells bearing BV4, BV14 and BV18 genes play a very important role in the etiology and pathogenesis of OLP. Supported by National Natural Science Foundation of China (30872888), Research Fund of Science and Technology Commission of Shanghai Municipality (06ZR14060) and Shanghai Leading Academic Discipline Project (S30206).