Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain.
Magn Reson Chem. 2011 Jul;49(7):437-42. doi: 10.1002/mrc.2755. Epub 2011 Mar 31.
Several pyridazin-3(2H)-one derivatives were synthesized starting from alkyl furans using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of the synthetic strategy followed. For all pyridazinones reported, a complete assignment of the (1)H and (13)C NMR spectra using one- and two-dimensional NMR spectroscopic methods, which included NOE, DEPT, COSY, HSQC and HMBC experiments, was accomplished. Correlations between the chemical shifts of the heterocyclic ring atoms and substituents at N-2 and C-6 were analyzed.
几种哒嗪-3(2H)-酮衍生物是从烷基呋喃开始，通过单线态氧氧化合成的，得到 4-甲氧基或 4-羟基丁内酯，这是所采用的合成策略的关键中间体。对于报道的所有哒嗪酮，都使用一维和二维 NMR 光谱方法（包括 NOE、DEPT、COSY、HSQC 和 HMBC 实验）完成了（1）H 和（13）C NMR 谱的完全归属。分析了杂环原子和 N-2 和 C-6 取代基的化学位移之间的相关性。
