Sørensen Jakob, Sjøgren Per
Palliativt Team, Nyborg Sygehus, 5800 Nyborg, Denmark.
Ugeskr Laeger. 2011 Mar 28;173(13):965-8.
Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.
阿片类药物广泛用作治疗恶性及非恶性来源慢性疼痛的镇痛药。在阿片类药物治疗期间，疼痛偶尔会加剧。这可能是由于疾病进展、耐受性或阿片类药物诱导的痛觉过敏（OIH）所致。本文总结了支持OIH存在的临床前和临床数据。此外，还概述了可能的机制和潜在的治疗方法。我们得出结论，关于OIH的临床研究较少。然而，越来越多的实验数据支持临床环境中存在OIH。评估OIH的诊断工具尚未开发出来。
