Indran Inthrani R, Tufo Grégory, Pervaiz Shazib, Brenner Catherine
Apoptosis, ROS and Cancer Biology Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
Biochim Biophys Acta. 2011 Jun;1807(6):735-45. doi: 10.1016/j.bbabio.2011.03.010. Epub 2011 Mar 29.
Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough understanding of apoptotic signaling pathways and insights into apoptosis resistance mechanisms are imperative to unravel novel drug targets for the design of more effective and target selective therapeutic strategies. This review aims at providing an overview of the recent understanding of apoptotic signaling pathways, the main mechanisms by which cancer cells resist apoptotic insults, and discusses some recent attempts to target the mitochondrion for restoring efficient cell death signaling in cancer cells.
凋亡缺陷或效率低下是癌细胞的一个后天特征。因此，全面了解凋亡信号通路并深入洞察凋亡抵抗机制对于揭示新的药物靶点以设计更有效且具有靶点选择性的治疗策略至关重要。本综述旨在概述对凋亡信号通路的最新认识、癌细胞抵抗凋亡损伤的主要机制，并讨论最近一些针对线粒体以恢复癌细胞中有效细胞死亡信号的尝试。
