Division of Allergy and Immunology, Center for Cancer and Blood Disorders, Children's National Medical Center, 111 Michigan Avenue, North West, Washington, DC 20010, USA.
Pediatr Clin North Am. 2011 Apr;58(2):315-26, ix. doi: 10.1016/j.pcl.2011.02.008.
Food allergies are immune-mediated responses to food proteins. Because of differences in the underlying immunologic mechanisms, there are varying clinical presentations of food allergy. This article discusses the manifestations of IgE-mediated disorders, including urticaria and angioedema, rhinoconjunctivitis, asthma, gastrointestinal anaphylaxis, generalized anaphylaxis, food-dependent exercise-induced anaphylaxis, and oral allergy syndrome. It also reviews the presentations of mixed IgE- and cell-mediated disorders, including atopic dermatitis and eosinophilic gastrointestinal disorders. Finally, the manifestations of cell-mediated food allergies are discussed, including dietary protein-induced proctitis and proctocolitis, food protein-induced enterocolitis syndrome, celiac disease, and food-induced pulmonary hemosiderosis.
食物过敏是针对食物蛋白的免疫介导反应。由于潜在免疫机制的差异，食物过敏有不同的临床表现。本文讨论了 IgE 介导的疾病的表现，包括荨麻疹和血管性水肿、鼻结膜炎、哮喘、胃肠道过敏反应、全身性过敏反应、食物依赖运动诱发的过敏反应和口腔过敏综合征。还回顾了混合 IgE 和细胞介导的疾病的表现，包括特应性皮炎和嗜酸性粒细胞性胃肠病。最后，讨论了细胞介导的食物过敏的表现，包括食物蛋白诱导的直肠结肠炎和直肠结肠炎、食物蛋白诱导的肠病综合征、乳糜泻和食物诱导的肺含铁血黄素沉着症。
