Division of Gastroenterology, Department of Surgery, Children's National Medical Center, Washington, DC, USA.
Pediatr Clin North Am. 2011 Apr;58(2):389-405, x. doi: 10.1016/j.pcl.2011.02.001.
The rates of eosinophilic gastrointestinal disorders appear to be increasing. The most common of these is eosinophilic esophagitis (EoE) which is a clinicopathologic condition consisting of characteristic symptoms and endoscopic features accompanied by a pan-esophageal, acid resistant epithelial eosinophilia of greater than equal to 15 per high power field. Typical symptoms include dysphagia and abdominal pain. Typical endoscopic features include pallor, plaques, furrows, concentric rings. Complications include food impactions and strictures. EoE resolution with food elimination diets provides evidence that EoE is a food-antigen driven process. In vitro and microarray studies have identified specific immunologic factors underlying EoE pathogenesis. Other gastrointestinal manifestations of food intolerances/allergy include food protein induced enterocolitis syndrome.
嗜酸性粒细胞性胃肠道疾病的发病率似乎正在上升。其中最常见的是嗜酸性食管炎（EoE），这是一种临床病理疾病，其特征为典型症状和内镜特征，同时伴有食管全层、抗酸上皮嗜酸性粒细胞增多，每高倍视野大于等于 15 个。典型症状包括吞咽困难和腹痛。典型的内镜特征包括苍白、斑块、皱襞、同心环。并发症包括食物嵌塞和狭窄。通过消除食物的饮食治疗可以使 EoE 得到缓解，这表明 EoE 是一种由食物抗原驱动的过程。体外和微阵列研究已经确定了 EoE 发病机制背后的特定免疫因素。食物不耐受/过敏的其他胃肠道表现包括食物蛋白诱导的结肠炎综合征。
