Godat Sébastien, Moradpour Darius, Schoepfer Alain
Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2011 Sep 7;7(307):1678-80, 1682.
Eosinophilic esophagitis (EoE) shows an increasing incidence and prevalence in western countries and is currently the main cause of dysphagia in adults. This disease is more prevalent in males and is frequently associated with allergies. Diagnosis is based on the presence of esophageal symptoms, dense eosinophilic esophageal infiltration, and the exclusion of other conditions associated with esophageal eosinophilia. Topical corticosteroids lead to a rapid clinical and histological improvement of active EoE. Especially in children, elimination diets can have similar efficacy as topical corticosteroids. Esophageal dilation of EoE-induced strictures can also be effective in improving symptoms, but this therapy has no effect on the underlying inflammation. Long-term therapeutic strategies have yet to be defined.
嗜酸性粒细胞性食管炎（EoE）在西方国家的发病率和患病率呈上升趋势，目前是成人吞咽困难的主要原因。这种疾病在男性中更为普遍，且常与过敏相关。诊断基于食管症状的存在、食管嗜酸性粒细胞密集浸润以及排除其他与食管嗜酸性粒细胞增多相关的疾病。局部使用皮质类固醇可使活动性EoE在临床和组织学上迅速改善。尤其是在儿童中，饮食消除疗法可产生与局部使用皮质类固醇类似的疗效。EoE引起的狭窄进行食管扩张也可有效改善症状，但这种治疗对潜在炎症无效。长期治疗策略尚未明确。
