Wasikowa R, Iwanicka Z, Pellar J, Hirowska I, Barg E
I. Kinderklinik der Medizinischen Akademie Wrocław.
Kinderarztl Prax. 1990 Jul;58(7):335-40.
The authors observed an occurrence of pubertas praecox vera by 42 girls from 8 months to 7 years of age. The purpose of the investigations was to elucidate the possible causes of the precocious symptoms and to estimate the effect of the therapy with various LHRH-analogues. Only in 2 children a cranial tumor was found. In the remaining cases an idiopathic precocious puberty was diagnosed. These children received a therapy with LHRH-analogues: Relefact, Busserelin or Decapeptyl. The authors obtained the best results with the slow releasing Decapeptyl.
作者观察到42名8个月至7岁女童出现真性性早熟。研究目的是阐明早熟症状的可能原因,并评估各种促性腺激素释放激素(LHRH)类似物的治疗效果。仅在2名儿童中发现了颅部肿瘤。其余病例被诊断为特发性性早熟。这些儿童接受了LHRH类似物治疗:Relefact、布舍瑞林或曲普瑞林。作者使用缓释曲普瑞林取得了最佳效果。