垂体 - 肾上腺功能对大鼠疼痛敏感性调节的影响。 - Suppr

The relationship between adrenalcortical hormones, adrenocorticotrophic hormone (ACTH), and pain sensitivity was investigated in the rat. Pain sensitivity was assessed by measuring paw-lick and jump latencies in response to being placed on a grid at 55 degrees C.2. Bilateral adrenalectomy increased the sensitivity to pain, but adrenal demedullation had no effect.3. Pain sensitivity was inversely related to the circadian changes in circulating corticosterone and was greater at 7 a.m. than at 7 p.m. However, the same variation in pain sensitivity existed if the adrenals were removed, suggesting that the increase in pain sensitivity after adrenalectomy was not related directly to the levels of corticosteriods.4. The time course of the increase in pain sensitivity after adrenalectomy paralleled that of the changes in circulating ACTH. Adrenalectomy markedly increased pain sensitivity at 9 and 18 days following surgery when circulating ACTH levels were markedly elevated and corticosterone was absent, but not at 3 days following adrenalectomy when ACTH levels were lower and corticosterone was absent.5. Hypophysectomy decreased the sensitivity to pain.6. The results indicate that ACTH can alter pain sensitivity and that the effect of corticosteroids on the sensitivity to pain is an indirect one by virtue of their negative feed-back action on the hypothalamic-pituitary system.

在大鼠中研究了肾上腺皮质激素、促肾上腺皮质激素（ACTH）与疼痛敏感性之间的关系。通过测量将大鼠置于55摄氏度的网格上时的舔爪和跳跃潜伏期来评估疼痛敏感性。
双侧肾上腺切除术增加了对疼痛的敏感性，但肾上腺髓质切除术没有效果。
疼痛敏感性与循环中皮质酮的昼夜变化呈负相关，上午7点时比晚上7点时更高。然而，如果切除肾上腺，疼痛敏感性也会出现相同的变化，这表明肾上腺切除术后疼痛敏感性的增加与皮质类固醇水平没有直接关系。
肾上腺切除术后疼痛敏感性增加的时间进程与循环中ACTH的变化平行。肾上腺切除术后9天和18天，当循环ACTH水平显著升高且皮质酮缺失时，疼痛敏感性显著增加，但在肾上腺切除术后3天，当ACTH水平较低且皮质酮缺失时，疼痛敏感性并未增加。
垂体切除术降低了对疼痛的敏感性。
结果表明，ACTH可以改变疼痛敏感性，并且皮质类固醇对疼痛敏感性的影响是通过它们对下丘脑 - 垂体系统的负反馈作用而产生的间接影响。

垂体 - 肾上腺功能对大鼠疼痛敏感性调节的影响。