Salivary Gland Center, Columbia University College of Dental Medicine, 630 West 168th St., New York, NY, USA.
J Am Dent Assoc. 2011 Apr;142(4):406-9. doi: 10.14219/jada.archive.2011.0195.
Oral transmucosal fentanyl citrate lozenges (lollipops) are indicated for the oral management of breakthrough cancer pain. When abused, these sucrose-containing lozenges can cause rampant dental caries.
The authors examined a 19-year-old man whose dentist referred him because of total dental coronal destruction. After the authors questioned the patient, they concluded that his frequent oral use of sucrose-containing opioid fentanyl citrate lozenges across a three-year period caused the dental condition.
Dentists should be aware that oral transmucosal fentanyl citrate lozenges are being prescribed off-label for the control of pain from nonmalignant sources. Fentanyl citrate's effective analgesic potency can lead to misuse and potential abuse. Early recognition of its misuse could prevent severe dental caries and the need for extensive dental restoration.
枸橼酸芬太尼口含舌下片（棒棒糖）用于口服管理突破性癌痛。当被滥用时，这些含蔗糖的棒棒糖会导致猖獗的龋齿。
作者检查了一名 19 岁的男子，他的牙医因全冠牙冠破坏将他转介过来。在询问了患者之后，作者们得出结论，他在三年内频繁地使用含蔗糖的阿片类药物枸橼酸芬太尼口含舌下片导致了这种口腔状况。
牙医应该意识到，枸橼酸芬太尼口含舌下片正在被超说明书用于控制非恶性来源的疼痛。芬太尼的有效镇痛效力可能导致误用和潜在滥用。早期识别其误用可以预防严重的龋齿和广泛的牙齿修复需求。
