雷尼替丁引起的血小板减少症：一种罕见的药物反应。
Ranitidine-induced thrombocytopenia: A rare drug reaction.
机构信息
Department of Skin and VD, Kasturba Medical College, Mangalore, India.
出版信息
Indian J Pharmacol. 2011 Feb;43(1):76-7. doi: 10.4103/0253-7613.75676.
H(2) antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed neutrophilia with normal blood picture. However repeat investigations showed falling WBC and platelet count. After excluding other causes of pancytopenia we concluded that ranitidine was the cause for this atypical drug reaction, more so when the blood picture improved within 72 hrs of ranitidine withdrawal.
H2 拮抗剂雷尼替丁引起的血小板减少症是一种罕见的药物现象。在这里，我们报告了一例 55 岁女性脓疱性银屑病患者，她出现发热和呕吐。患者开始使用罗红霉素、静脉注射昂丹司琼、扑热息痛和静脉注射雷尼替丁。全血细胞计数显示中性粒细胞增多，血象正常。然而，重复检查显示白细胞和血小板计数下降。排除其他全血细胞减少症的原因后，我们得出结论，雷尼替丁是这种非典型药物反应的原因，更确切地说，在停用雷尼替丁后 72 小时内血象改善。
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