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致命性皮肤类圆线虫病作为使用霉酚酸酯治疗落叶型天疱疮的一种副作用。

Fatal cutaneous Strongyloidiasis as a side effect of Pemphigus foliaceus treatment with mycophenolate mofetil.

作者信息

Vitiello Magalys, Shelling Michael, Camacho Ivan, Milikowski Clara, Kerdel Francisco A

机构信息

Department of Dermatology and Cutaneous Surgery, L. Miller School of Medicine, University of Miami, Miami, FL, USA.

出版信息

J Drugs Dermatol. 2011 Apr;10(4):418-21.

PMID:21455554
Abstract

Strongyloidiasis is caused by the roundworm Strongyloides stercoralis (S. stercoralis). It is uncommon in the Unites States, and most cases are brought by travelers who have visited or lived in South America or Africa. Individuals with an intact immune system may experience mild gastrointestinal symptoms or none at all. In contrast, those with a compromised immune system may develop a rapidly fatal infection, commonly referred to as hyperinfection syndrome or disseminated Strongyloidiasis. We present a 66-year-old inmunocompromised male with Pemphigus Foliaceus who was admitted to the intensive care unit in critical condition and in whom a skin biopsy prove to be the main tool in the diagnosis of Strongyloidiasis.

摘要

粪类圆线虫病由粪类圆线虫(S. stercoralis)引起。在美国并不常见,大多数病例是由去过或居住在南美洲或非洲的旅行者带入的。免疫系统正常的个体可能会出现轻微的胃肠道症状,也可能根本没有症状。相比之下,免疫系统受损的个体可能会发展为迅速致命的感染,通常称为播散性粪类圆线虫病或高度感染综合征。我们报告了一名66岁患有落叶型天疱疮的免疫功能低下男性,他因病情危急被收入重症监护病房,皮肤活检被证明是诊断粪类圆线虫病的主要手段。

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