糖化血红蛋白、低血糖和 2 型糖尿病日本患者高血糖之间的关系——来自连续血糖监测数据的结果。

Relationship among A1C, hypoglycemia, and hyperglycemia in Japanese with type 2 diabetes--results from continuous glucose monitoring data.

机构信息

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.

出版信息

Diabetes Technol Ther. 2011 Jun;13(6):667-70. doi: 10.1089/dia.2010.0230. Epub 2011 Apr 2.

DOI:10.1089/dia.2010.0230

PMID:21457068

Abstract

BACKGROUND

The intensive treatment aimed at achieving optimal A1C may increase a risk of hypoglycemia. Therefore, we examined the rate and duration of hypoglycemia (<70 mg/dL) and the duration of hyperglycemia (≥200 mg/dL) according to their A1C status, using continuous glucose monitoring (CGM) in Japanese patients with type 2 diabetes who were treated with hypoglycemic agents.

METHODS

Forty subjects were equally divided into three groups according to their A1C levels (low, intermediate, and high A1C groups). The 24-h CGM data were collected immediately upon admission to hospital with the patients continuing to take the same medications they had prior to hospitalization.

RESULTS

There was a significant difference in the total duration of hyperglycemia among the groups, with the low A1C group having a median duration of hyperglycemia of 50 min (25-75(th) percentile, 0-550 min) compared with 302.5 min (220-500 min) in the intermediate A1C group and 660 min (185-830 min) in the high A1C group. However, the incidence rate and total duration of hypoglycemia were similar for all A1C groups.

CONCLUSION

The A1C level did not predict the presence or the duration of hypoglycemia.

摘要

背景

旨在实现最佳 A1C 的强化治疗可能会增加低血糖的风险。因此，我们使用连续血糖监测（CGM）检查了使用降糖药物治疗的 2 型糖尿病日本患者根据 A1C 状态的低血糖（<70mg/dL）和高血糖（≥200mg/dL）的发生率和持续时间。

方法

40 名患者根据 A1C 水平（低、中、高 A1C 组）平均分为三组。入院时立即收集 24 小时 CGM 数据，患者继续服用与入院前相同的药物。

结果

各组之间高血糖总持续时间存在显著差异，低 A1C 组高血糖中位数持续时间为 50 分钟（25-75 百分位，0-550 分钟），而中 A1C 组为 302.5 分钟（220-500 分钟），高 A1C 组为 660 分钟（185-830 分钟）。然而，所有 A1C 组的低血糖发生率和总持续时间相似。