Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, Franklin Wilkins Building, Waterloo Campus, King's College London, 150 Stamford Street, London SE1 9NH, UK.
Trends Pharmacol Sci. 2011 Apr;32(4):197-200. doi: 10.1016/j.tips.2011.02.006. Epub 2011 Mar 31.
Paradoxical pharmacology is a term first suggested by Richard Bond to refer to intriguing observations that chronic use of some drug types can have the opposite biological effect(s) to those seen following acute administration of the same drug. A good example of 'paradoxical pharmacology' is the research Richard has pioneered showing that whereas acute administration of β-blockers is contraindicated in the treatment of asthma, chronic use of certain β-blockers can have therapeutic benefit. It would appear that those β-blockers that can act as inverse agonists at the β2 receptor particularly show this paradoxical effect and the findings of Richard's research not only challenge the dogma of the treatment of asthma but also challenge many of the pharmacological principles of ligand/receptor interactions established by Sir James Black and others. In this paper, I discuss Richard's efforts to evaluate the chronic effects of β-blockers in the airways and how this research caught the imagination of Sir James Black.
矛盾药理学是理查德·邦德（Richard Bond）首先提出的一个术语，用于指代一些令人好奇的观察结果，即长期使用某些药物类型可能会产生与同一药物急性给药后观察到的相反的生物学效应。“矛盾药理学”的一个很好的例子是理查德开创的研究，表明尽管β受体阻滞剂的急性给药在哮喘治疗中是禁忌的，但某些β受体阻滞剂的慢性使用可能具有治疗益处。似乎那些可以作为β2受体反向激动剂的β受体阻滞剂尤其表现出这种矛盾的效果，理查德的研究结果不仅挑战了哮喘治疗的教条，也挑战了詹姆斯·布莱克爵士（Sir James Black）和其他人建立的配体/受体相互作用的许多药理学原则。在本文中，我将讨论理查德评估β受体阻滞剂在气道中的慢性作用的努力，以及这项研究如何引起詹姆斯·布莱克爵士的兴趣。
