Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Molecular Immunology, Marchioninistrasse 25, Munich, Germany.
Eur J Cell Biol. 2012 Jan;91(1):48-52. doi: 10.1016/j.ejcb.2011.02.001. Epub 2011 Mar 31.
Heat shock proteins (Hsps) hold a dual role depending on their location. Inside cells, they fulfill essential survival functions as molecular chaperones forming complexes with intracellular polypeptides (self or foreign) to help in protein folding, the resolution of protein aggregates and intracellular protein transport. Released from the cell, they act as messengers communicating the cells' interior protein composition to the immune system for initiation of immune responses against intracellular proteins. Here we describe the mechanisms by which Hsp70, the heat-inducible Hsp70 family member, crosstalks with the immune system. Further, we discuss that clinical hyperthermia could be a way to initiate the immunologic activity of Hsp70 by upregulating its expression and facilitating release through local necrosis.
热休克蛋白 (Hsps) 根据其位置具有双重作用。在细胞内，它们作为分子伴侣与细胞内多肽（自身或外来）形成复合物，发挥重要的生存功能，帮助蛋白质折叠、解决蛋白质聚集和细胞内蛋白质运输。从细胞中释放出来后，它们作为信使将细胞内的蛋白质组成传递给免疫系统，引发针对细胞内蛋白质的免疫反应。在这里，我们描述了热诱导型 Hsp70 家族成员 Hsp70 与免疫系统相互作用的机制。此外，我们还讨论了临床高温疗法可以通过上调其表达并通过局部坏死促进其释放来启动 Hsp70 的免疫活性。
