Department of Pathology, University of Pittsburgh Medical Center, United States.
Pathol Res Pract. 2011 May 15;207(5):275-8. doi: 10.1016/j.prp.2011.02.005. Epub 2011 Apr 1.
Idiopathic granulomatous orchitis is a rare inflammatory process of the testis of unknown etiology. It is characterized by presence of non-specific granulomatous inflammation and admixed multinucleated giant cells. It usually presents as a testicular mass which is highly suspicious of malignancy. Histologically, there is extensive destruction of seminiferous tubules with tubular or interstitial pattern of granulomatous inflammation and prominent collagen fibrosis. Trauma and possible auto-antibodies against sperms have been postulated to be the underlying mechanism. Differential diagnoses include intratubular germ-cell neoplasia, malignant lymphomas, and malakoplakia. Orchiectomy is currently the most appropriate therapy for this condition.
特发性肉芽肿性睾丸炎是一种罕见的睾丸不明原因炎症性疾病。其特征为存在非特异性肉芽肿性炎症和混杂多核巨细胞。通常表现为睾丸肿块，高度怀疑为恶性肿瘤。组织学上，广泛破坏曲细精管，呈管状或间质样肉芽肿性炎症，胶原纤维显著纤维化。推测创伤和可能针对精子的自身抗体是潜在的发病机制。鉴别诊断包括管内生殖细胞肿瘤、恶性淋巴瘤和类脂性肉芽肿。目前，睾丸切除术是这种疾病最恰当的治疗方法。
