三氨基嘧啶和吡啶类作为组氨酸 H(4)受体调节剂。
Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.
机构信息
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2011 May 15;21(10):3113-6. doi: 10.1016/j.bmcl.2011.03.017. Epub 2011 Mar 30.
PMID:21458260
Abstract
Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H(4) receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.
摘要
已经合成了两个系列的三氨基嘧啶和一系列三氨基吡啶，并对它们在 H(4)受体的竞争性结合和功能测定中的活性进行了结构-活性关系评估。这些杂芳环核心的微小结构变化影响了这些化合物的功能活性。
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