Department of Chemistry, Tongji University, Shanghai 200092, PR China.
J Photochem Photobiol B. 2011 May 3;103(2):186-91. doi: 10.1016/j.jphotobiol.2011.03.006. Epub 2011 Mar 16.
Hydrogen sulfide is the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide. Recent studies showed that hydrogen sulfide could alleviate many diseases which were related to the oxidative damage of tissues. It reminded us that hydrogen sulfide might serve as an antioxidant to reduce oxidative pressure. This study showed that hydrogen sulfide protected lysozyme from photo-oxidation induced by riboflavin (RF). Laser flash photolysis was used to explore the mechanisms of antioxidant activity of hydrogen sulfide. The scavenging effects of hydrogen sulfide on the triplet state of riboflavin (³RF(*)) and radicals of tryptophan and tyrosine (TyrO· and TrpN·) were attributed to the protection of lysozyme from photo-oxidation. The results suggested that hydrogen sulfide could serve as an antioxidant in alleviation of oxidative pressure.
硫化氢是继一氧化氮和一氧化碳之后的第三种内源性信号气体递质。最近的研究表明，硫化氢可以缓解许多与组织氧化损伤有关的疾病。这提醒我们，硫化氢可能作为一种抗氧化剂来减轻氧化压力。本研究表明，硫化氢可以保护溶菌酶免受核黄素（RF）光氧化诱导。激光闪光光解用于探索硫化氢抗氧化活性的机制。硫化氢对核黄素三重态（³RF(*)）和色氨酸和酪氨酸自由基（TyrO·和TrpN·）的清除作用归因于对溶菌酶光氧化的保护。结果表明，硫化氢可以作为一种抗氧化剂来缓解氧化压力。
