High-resolution NMR spectroscopy in unstable and inhomogeneous fields via stroboscopic acquisition.

In this paper, we demonstrated that despite the insensitivity of intermolecular zero-quantum coherences (iZQCs) to B(0) variations, the influence of unstable fields on the observable single-quantum coherence signals causes strong t(1) noises in the high-resolution iZQC projection spectra. Stroboscopic acquisition was then proposed for noise suppression. The feasibility of the modified sequences with the proposed acquisition scheme was verified by computer simulations and experiments in different unstable fields generated by the Z0 and Z1 coil current oscillations, which mimic the unstable fields of NMR using externally powered magnets and MRS in the presence of physiological motions, respectively.