Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK.
Clin Res Hepatol Gastroenterol. 2011 Jun;35(6-7):446-54. doi: 10.1016/j.clinre.2011.02.007. Epub 2011 Apr 1.
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) represent major indications for liver transplantation (LT). Despite the steady increase in the incidence and prevalence of PBC, the number of liver transplants for PBC has fallen in recent years, whereas the number of transplants for PSC has remained stable. Indications for LT for PBC and PSC are no different from those of other causes of chronic liver disease, apart from some disease-specific indications. PBC and PSC have more favourable outcomes after LT, compared to viral hepatitis and alcohol-associated liver disease. Numerous studies have clearly demonstrated that PBC and PSC recur after LT. The diagnosis of recurrent disease should be made on agreed criteria. The impact of recurrent disease on survival is unclear. Study of recurrent PBC and PSC may provide a better understanding of the mechanisms of these diseases in the native liver.
原发性胆汁性肝硬化（PBC）和原发性硬化性胆管炎（PSC）是肝移植（LT）的主要适应证。尽管 PBC 的发病率和患病率稳步上升，但近年来用于 PBC 的肝移植数量有所下降，而 PSC 的移植数量保持稳定。除了一些特定于疾病的适应证外，PBC 和 PSC 的 LT 适应证与其他慢性肝病的适应证没有区别。与病毒性肝炎和酒精性肝病相比，PBC 和 PSC 在 LT 后有更好的结局。许多研究清楚地表明，PBC 和 PSC 在 LT 后会复发。复发性疾病的诊断应根据商定的标准进行。复发性疾病对生存的影响尚不清楚。对复发性 PBC 和 PSC 的研究可能有助于更好地了解这些疾病在原肝中的发病机制。
