Flood J F, Mooradian A D, Morley J E
Geriatric Research, Education, and Clinical Center, Veterans Administration Hospital, St. Louis, Missouri.
Diabetes. 1990 Nov;39(11):1391-8. doi: 10.2337/diab.39.11.1391.
We demonstrated that mice with streptozocin-induced diabetes mellitus have normal acquisition for relatively simple tasks but show problems in learning more complex tasks such as shuttle box avoidance. Enhanced learning previously reported in simple passive avoidance tasks appears to be due to increased foot shock sensitivity. Diabetic mice show a marked memory retention deficit after learning an active avoidance T-maze task. This retention deficit was reversed by a single injection of insulin, suggesting that it may be related to hyperglycemia per se. Diabetic mice have a shift to the left in the inverted U-shaped dose-response curve for memory retention produced by the acetylcholine agonist arecoline. Based on a preliminary screening, responses to several other pharmacological memory enhancers are probably altered in diabetic mice. These studies suggest that this mouse model of diabetes mellitus demonstrates a deficit in memory retention and retrieval similar to that seen in humans with diabetes mellitus.
我们证明，链脲佐菌素诱导的糖尿病小鼠在相对简单的任务中具有正常的习得能力，但在学习更复杂的任务（如穿梭箱回避任务）时存在问题。先前报道的在简单被动回避任务中增强的学习似乎是由于足部电击敏感性增加所致。糖尿病小鼠在学习主动回避T迷宫任务后表现出明显的记忆保持缺陷。单次注射胰岛素可逆转这种保持缺陷，这表明它可能与高血糖本身有关。糖尿病小鼠对乙酰胆碱激动剂槟榔碱产生的记忆保持的倒U形剂量反应曲线向左偏移。基于初步筛选，糖尿病小鼠对其他几种药理学记忆增强剂的反应可能发生改变。这些研究表明，这种糖尿病小鼠模型表现出与糖尿病患者类似的记忆保持和检索缺陷。
