Department of Analytical Chemistry, University of Vienna, Vienna, Austria.
Anal Bioanal Chem. 2011 Jun;400(8):2507-15. doi: 10.1007/s00216-011-4927-1. Epub 2011 Apr 3.
Polymers as coating materials were combined with quartz crystal microbalances (QCMs) to design sensor devices for the detection of both ionic and neutral analytes in liquid phase. The design and geometry of dual and tetraelectrode QCMs have been optimized to reduce electric field interferences. An unusual Sauerbrey effect was observed while exposing potassium salt solution to 10- and 20-MHz QCMs, i.e. increase in the frequency shifts by a factor of seven, which is attributed to electro-acoustic phenomena. Non-functionalized sol-gel materials were synthesized by templating with hydrophobic salt such as tetraethyl ammonium picrate. Imprinting with these ions of low charge density leads to sensitive layers, and UV-Vis spectroscopy was used to check re-inclusion of this analyte. In the next strategy, functionalized polyurethane for potassium ions and sol-gel materials with aminopropyl group as ligand were generated to tune selectivity and sensitivity towards Ni(2+) and Cu(2+). Methacrylic acid polymers were optimized for the detection of atrazine by hydrogen bonding; double molecular imprinted polyurethane approach was followed for pyrene recognition. Finally, these imprinted polymers were combined with tetraelectrode QCM to develop sensor platform.
聚合物作为涂层材料与石英晶体微天平（QCM）相结合，设计用于检测液相中离子和中性分析物的传感器装置。双电极和四电极 QCM 的设计和几何形状经过优化，以减少电场干扰。当将钾盐溶液暴露于 10-和 20-MHz QCM 时，观察到异常的 Sauerbrey 效应，即频率偏移增加了七倍，这归因于电声现象。通过用疏水性盐（如四乙基硝酸铵）模板合成非功能化溶胶-凝胶材料。用这些低电荷密度的离子印迹会导致敏感层，并使用 UV-Vis 光谱检查对该分析物的再包容。在下一个策略中，生成了用于钾离子的功能化聚氨酯和具有氨丙基作为配体的溶胶-凝胶材料，以调节对 Ni(2+)和 Cu(2+)的选择性和灵敏度。通过氢键优化了用于检测莠去津的甲基丙烯酸聚合物；采用双分子印迹聚氨酯方法识别苝。最后，将这些印迹聚合物与四电极 QCM 结合，开发了传感器平台。
