Speranskaia N V, Nekrasova A A, Bankuzova E V, Shkhvatsabaia I K
Kardiologiia. 1978 Nov;18(11):46-51.
The reaction of cyclic nucleotides in blood to an orthostatic position, furosemid administration, and submaximal bicycle ergometry load was studied in 20 healthy individuals and in 50 patients with hypertensive disease. A special group was composed of 25 patients the disease in whom was marked by crises. It is shown that a walk of one hour and intravenous infusion of 40 mg of furosemid caused an increase in the blood cAMP but did not change the level of cGMP. During a bicycle ergometry load the levels of cGMP and cGMP increased to an equal measure and returned to their initial values 30 min after its cessation. In patients with arterial hypertension the cGMP system becomes most functionally mobile, whereas the cAMP level, if it increases, does so at a later term after the effect of the stimulus begins. The increased cGMP level is maintained for quite a lengthy period of time after the load is discontinued. In patients suffering from hypertensive disease with crises the cAMP/cGMP ratio, which is reduced at rest also, diminishes still more in an orthostatic position and particularly during a crisis. The role of changes in the metabolism of cyclic nucleotides and their sensitivity to regulatory factors in the pathogenesis of arterial hypertension is discussed.
在20名健康个体和50名高血压患者中，研究了血液中环状核苷酸对直立位、给予速尿以及次极量自行车测力计负荷的反应。一个特殊组由25名以病情发作显著为特征的患者组成。结果显示，步行一小时和静脉输注40毫克速尿会导致血液中环磷酸腺苷（cAMP）增加，但不会改变环磷酸鸟苷（cGMP）的水平。在自行车测力计负荷期间，cGMP和cAMP的水平等量增加，并在负荷停止30分钟后恢复到初始值。在动脉高血压患者中，cGMP系统在功能上最为活跃，而cAMP水平如果增加，则在刺激作用开始后的较晚阶段才会增加。负荷停止后，升高的cGMP水平会维持相当长一段时间。在患有伴有发作的高血压疾病的患者中，cAMP/cGMP比值在静息时就已降低，在直立位时会进一步降低，尤其是在发作期间。讨论了环状核苷酸代谢变化及其对调节因子的敏感性在动脉高血压发病机制中的作用。
