Negura D, Micheletti A, Chessa M, Calaciura R, Saracino A, Butera G, Piazza L, Arcidiacono C, Carminati M
Centro di Cardiologia-Cardiochirurgia Pediatrica e Cardiopatie Congenite dell'Adulto, I.R.C.C.S.-Policlinico San Donato, San Donato Milanese, Milano, Italy.
Pediatr Med Chir. 2010 Nov-Dec;32(6):256-9.
Cardiopulmonary exercise testing (CPET) gives important information about functional capacity by direct measurement of exercise respiratory gas exchange. It provides assessment of the integrative exercise responses involving the cardiovascular, respiratory and muscle-skeletal systems which are not adequately investigated through the measurement of individual organ system function. CPET involves measurements of oxygen uptake (VO2), carbon dioxide production (VCO2) and several ventilatory measures. CPET is increasingly being used as a clinical tool to determine functional capacity, prognosis and potential need for medical or surgical interventions in patients affected by congenital heart disease (CHD). Also in this population, peak VO2 and slope VE/VCO2 are the most predictive parameters in terms of mortality and need of hospitalization. Cyanotic patients with Esisenmenger syndrome show the worst functional limitation and consequently the worst prognosis. This article provides basic and practical information about CPET and focuses on its interpretation in patients with CHD.
心肺运动试验（CPET）通过直接测量运动时的呼吸气体交换，提供有关功能能力的重要信息。它能评估涉及心血管、呼吸和肌肉骨骼系统的综合运动反应，而通过测量单个器官系统功能无法充分研究这些反应。CPET包括测量摄氧量（VO2）、二氧化碳产生量（VCO2）和多项通气指标。CPET越来越多地被用作一种临床工具，以确定先天性心脏病（CHD）患者的功能能力、预后以及医疗或手术干预的潜在需求。在这一人群中，峰值VO2和VE/VCO2斜率在死亡率和住院需求方面也是最具预测性的参数。患有艾森曼格综合征的青紫型患者表现出最严重的功能受限，因此预后最差。本文提供了有关CPET的基础和实用信息，并重点关注其在CHD患者中的解读。
